ea0077p45 | Metabolism, Obesity and Diabetes | SFEBES2021
Tan Arnold
, Evans Alexander
, Creighton Jade
, Boocock David
, Weir Nick
, Sale Craig
, Doig Craig
The nicotinamide adenine dinucleotide (NAD+) dependent Poly-(ADP-ribosyl)polymerase 1 (PARP1) generates the post-translational modification ADP-Ribosylation (ADPR). Molecular studies have identified potential for NAD+ consuming enzymes to influence metabolic function. Given that PARP1 determines cellular NAD+ concentrations and ADPR shifts target protein activity, we sought to identify the molecular actions of PARP1 within skeletal muscle. Analysis of C2C12 lysates demonstrate...